Population Genetics Report Fell Ponies Foal Immunodeficiency Syndrome Biology Essay

Adequate Equus caballus dodos have been found so that archeologists are able to follow the development of Equus caballuss. The earliest dodo of a Equus caballus found was a Canis familiaris sized Eohippus ( Tyagi, 2009 ) . This four toed Eohippus lived around 55 million old ages ago ( Hall, 2010 ) . The Equus largely stayed the same with the exclusion of little toe and teeth alterations. During the Oligocene epoch about 34-34 million old ages ago the Equus caballus grew in size and 4 toes evolved into 3. Besides in this clip the Equus caballus had vanished from Europe, Africa and Asia and for the undermentioned million old ages the lone topographic point which was habitable for the Equus caballus was in the western portion of North America ( Rice, 2007 ) . The Miocene epoch saw exuberant flora disappear and the land became a grassy field. The Equus caballus was forced to accommodate and germinate in order to last in this new environment, for illustration its dentitions needed to alter so it was able to masticate the new nutrient, its toes changed into hooves which made it easier to acquire about the different landscapes. These Equus caballuss are thought to hold had a similar encephalon and grinders to the modern Equus caballus of today ( Kimball 2006 ) .

The lone existent wild Equus caballus, to compare to the domesticated Equus caballus is the Przewalski ‘s Equus caballus, although this species is nonextant in the wild, there are some confined in menagerie which have saved the species from entire extinction and are now being confined bred ( Boyd 1994 ) .

The Fell pony originates from the England/Scotland boundary line. They are merely a little strain around 14h upper limit but are capable of transporting an grownup adult male ( Davis, 2008 ) . They are a difficult and hardy strain and besides versatile. The Fell pony matures late and will non engender frequently until every bit late as 7 old ages old. Most of the native Hides are left to roll free until the age of 2 or 3 and they are n’t overfed. Mares should n’t engender before the age of 3 or lasting harm could be done to the generative variety meats and the female horses adulthood and growing can be restricted ( Fell pony society, 2006 ) .

1.1 Environmental Factors

Survival of the fittest means that merely the strongest most resourceful animate beings live to engender. In the bad winter of 1946-47 most of the pure bred native ponies survived, but cross-breeds died. This winter was so bad that all but one group of Fell ponies that were cut off by deep snow for 6 hebdomads besides perished ( Richardson, 2008 )

The environment influences a Equus caballuss characters, for illustration weight and musculus, these all depend on nutrition and exercising. The athletic ability and disposition besides changes with different environmental factors. The size of the pony was due to the quality of graze, ponies that were bigger than 13hh could non hold survived on the moorland as their nutrient consumption would necessitate to be greater than the smaller ponies ( Mills, 2005 ) .

Demographic profiling of Equus caballus domestication is difficult. Mongol herds show the selective slaughter of entires at 2 and half old ages old, go forthing the female horses to last ( Zeder, 2006 ) .

A Equus caballus ‘s strain typical behavior is reflected on the combination of two forces- physical environment and worlds. Disposition differences are frequently linked with blood temperature ( Jensen, 2009 )

1.2 Human intercession

In early history of the Fell Pony, their beginnings were from autochthonal ponies of the part, and in the Roman period of Northern England the Equus caballuss were cross-bred with Equus caballuss which were introduced by foreign soldier of fortunes. These Equus caballuss from Friesland part have the pre-potency and features still seen today in the Fell pony ( Richardson, 2008 )

There was besides a mixture of Galloway blood, besides Welsh hazelnut from the entire Comet. Small sum of Andalusian blood and eventually Yorkshire trotter, which explains the larger 14.2hh ponies when the strain bound is 14hh ( Fell pony Society, 2009 ) . During the industrial revolution the Fell pony was used as a battalion pony. They carried up to 16 rock of lead, Fe ore, slate and coal from the mines. These ponies travelled 240 stat mis a hebdomad. From Kendal 300 Fells left to travel over the state transporting ladings such as fish, grain, poulets and dairy merchandises ( Hamlets house, n.d. )

The Fell pony society was created in 1916 and has the Queen Elizabeth II as the frequenter ( Fell pony society, 2003 ) . During the depression of the thirtiess along with mechanization the Fell pony strain was threatened and in 1932 at a entire show at that place was merely 3 ponies that were shown. King George V saved the Fell pony strain with a big contribution and besides Beatrix Potter donated to salvage this strain ( Richardson, 2008 )

Low engendering Numberss can drastically cut down the cistron pool in a strain, doing it to bottle cervix. This happened to the Fell ponies. In 1914, 5 entires were the direct descendent of the celebrated Blooming Heather. Homozygosity is 54 % in British rare strain Equus caballuss. ( Richardson, 2008 )

In today ‘s footings, nature is taking out of the equation ; there is no longer endurance of the fittest among these Equus caballuss. We provide them nutrient and shelter, there is no longer natural choice ( Richardson, 2008 ) . Humans took Equus caballuss from their environment in which they had evolved, and managed them under convenient conditions for us ( Waran, 2007 )

These yearss the Fell pony is used by adult male for demoing, siting and driving. The Fell pony society on a regular basis holds public presentation tests where the Equus caballus tackles different terrains such as marshy waies and H2O crossing. These Equus caballuss are smart and need to be kept active ( The Fell pony society, 2009 ) .

2. Gene flow and polygenic heritage of traits

Not all Fell ponies are black. There are besides brown, bay and gray ponies. Black did n’t go the chief coloring material until the terminal of twentieth century, before this clip dark bay was merely every bit common as the black ponies ( Fell Pony Museum, 2010 ) .

The two races of wild Equus caballuss are the Tarpan and Przewalski ‘s Equus caballus. During domestication female horses were crossed with entires that had more desirable features. It is assumed that female horses from different parts were varied in morphology because of the version to their environmental conditions. Gene flow ( migration ) is the chief ground for deficiency of phylogeographic construction. As Equus caballuss are so active migration degrees are high. Two wild Equus caballuss were found to hold indistinguishable haplotypes from the Pleistocene epoch, one from Germany and the other Siberia ( Kavar, 2008 )

The coloring material of a Equus caballus is built on a base of two colorss merely, black- Tocopherol and chestnut e. The coloring material of a Equus caballus is controlled by cistrons at 12 different venue ( Thiruvenkadan, 2008 ) . The two familial venues: Extension and Agouti control the black or chestnut coloring material of a Equus caballus ( Sponenberg, 2003 ) . Black is dominant over chestnut, and chestnut is hence recessionary. A Equus caballus that carries 2 black cistrons EE will be homozygous- black, a Equus caballus that carries one black cistron and one chestnut cistron ‘Ee ‘ will besides be black nevertheless it will be heterozygous, and eventually a Equus caballus that carries two chestnut cistrons ‘ee ‘ will ever be homozygous, chestnut.

If two heterozygous black Equus caballuss are bred together ‘Ee+Ee ‘ there will be a 1 in 4 opportunity of bring forthing a black homozygous ‘EE ‘ , 2 out of 4 opportunities of a black heterozygous ‘Ee ‘ and a 1 in 4 opportunity of a chestnut being produced ( Wellman, 2009 ) . See table 1.

Polygenic heritage is seen in a assortment of coloring material forms in Equus caballuss, such a shadiness and mane and chase coloring material. These might be due to influence of multiple cistrons ( Thiruvenkadan, 2008 ) .

Gene function has been used to delegate legion coat coloring material traits and upsets that are inherited to the Equus caballus chromosome. Molecular familial surveies for coat coloring material in Equus caballuss have helped place the cistrons and mutants which are responsible for coat coloring material fluctuation. Microsatellite markers that linked to the trait were besides found ( Thiruvenkadan, 2008 ) . Microsatellite loci trials across Equus caballus population showed that the highest ascertained heterozygosity of 0.0782 and highest diverseness of 0.779 was the Fell pony, the lowest was in the Friesian Equus caballus ( Luis, 2007 ) . Microsatellites show high allelomorphic diverseness and are used to cipher familial distance between the strains ( Mills, 2005 ) .

Table 1. Common allelomorphs at Agouti and extension venue.

Beginning: Sponenberg ( 2003 ) .

Agouti genotype

Extension genotype

Colour phenotype

AA –



Aa Aa




Ee Ee

Chestnut ( common )

Aa Aa

Ee Ee

Chestnut ( uncommon )

Any Equus caballus strain bing today is an look of the history of familial impetus and choice. The genotype for a strain will incorporate cistrons and combinations which code for specific features, ( such as good disposition and intelligence in Fells ( Simper, 2003 ) ) .

Foal Pony Syndrome

Mutants that occur in a cistron make it faulty or slightly unusual ( Guttman et al 2002 ) . This is seen as a hurtful cistron in the Fell pony.

In the early 80 ‘s it became cognizant that new born foals were deceasing from an unknown disease which could n’t be cured by traditional medical specialties. After post-mortem scrutinies the decision came that is was most likely something of familial beginning ( Brunt 2000 ) .

Fell pony foals get a status called immunodeficiency upset ( Fell pony syndrome ) . Plate 1 shows a foal with the syndrome. It affects foals less than 3 old ages of age. Both sexes get it ; the marks are diarrhoea, pneumonia, lymphocytopenia, ulcers on lingua, a curly coat which is remarkably long and decease ( Higgins, 2006 ) . Blood samples from the foals revealed that there is a low ruddy blood cell count, low lymph cell count and a high white cell count. A diagnosing can be made from a bone marrow sample taken from the sternum. The syndrome causes terrible anemia, impaired unsusceptibility and is fatal with the foals normally being put down or deceasing by the age of 3-4 months. As the syndrome is merely known in the Fell pony strain it is assumed that it ‘s of familial beginning ( Thomas, 2000 ) .Foals normally fall ill around 4 hebdomads of age. This status is perchance caused by an autosomal recessive hurtful cistron which is inherited ( Higgins, 2006 )

FIS Pony hypertext transfer protocol: //upload.wikimedia.org/wikipedia/commons/2/2e/Shetland_pony_inbred.jpg

Plate 1. Plate 2

( Animal wellness trust, no day of the month ) ( Wikipedia, inbreeding, 2008 )

Due to the Fells little cistron pool this syndrome is increasing at an dismaying rate, as it is estimated that merely 5000-6000 ponies are left world-wide. Selective genteelness is better than the riddance of bearers when engendering to avoid a syndrome foal. If the syndrome is proved to be of familial cause and the bearers can be found so they should n’t extinguish the bearer ponies from the engendering stock as contracting the little cistron pool any farther would hold a annihilating consequence to the strain ( Thomas, 2000 ) . The degree of FPS in the Fell pony population may be due to the history of the strain as after the Second World War there was a immense autumn in Numberss. This resulted in familial constriction ( Horse Trust, 2008 ) .

It is likely that two- tierces of the Fell pony population is a bearer, and 10-20 % of foals a twelvemonth are syndrome foals. No affected foals have been known to last ( Thomas, 2000 ) . The root cells in bone marrow are by and large losing in the syndrome foals. The bone marrow matrix might be neglecting to bring forth the root cells and be lacking ( Millard, 2000 ) .The most likely cause of the syndrome beginning is thought to hold been inbreeding/line genteelness in the sixtiess ( Plate 2 ) . The original bearer entire is n’t known but there is one to a great extent used entire in the fiftiess that is noticed in the lineage of each known syndrome foal ( Thomas, 2000 )

The lone manner of acquiring rid of this familial job is with carefully managed genteelness. Familial upsets are common and the direction of genteelness has been seen in other animate being strains which have worked successfully for them ( Brunt, 2000 ) . The Fell pony society is executing changeless familial trials to seek and extinguish the syndrome from the strain. The breeders are working with the society to continue the Fell pony strain. Carries can still be bred to a trial clear pony ; this will halt the loss of desirable strain traits. The foals can be DNA tested to see whether they are a bearer or non. A veterinarian can roll up samples and have them sent to a familial lab to find whether they are a bearer of the hurtful cistron or non ( Animal wellness trust, N.D )

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